A key role for Canoes intrinsically disordered region in linking cell junctions to the cytoskeleton
Corbin C. Jensen, Noah J. Gurley, Avery J. Mathias, Leah R. Wolfsberg, Yufei Xiao, Zixi Zhou, Maik C. Bischoff, Sarah E. Clark, Kevin C. Slep, Mark A. Peifer
The paper identifies conserved stickers in the Canoe IDR that bind F-actin, showing their combinatorial role in junctional localization, mechanosensing, and function during morphogenesis.
The Journal of Cell Biology · Sep 10, 2025Peer-reviewedCell Biology