Sarah Elizabeth Clark

Amoxicillin Worsens Mortality from Viral Respiratory Tract Infection

This study shows that amoxicillin use during influenza A infection increases mortality and worsens secondary bacterial pneumonia, particularly in males.

Myeloid cell reprogramming drives enhanced defense against Streptococcus pneumoniae lung infection following exposure to commensal Prevotella

The paper shows that exposure to Prevotella melaninogenica reprograms myeloid cells to enhance defense against Streptococcus pneumoniae lung infection.

Amoxicillin induces gut dysbiosis leading to long term suppression of type-17 immune tone in the lungs

This study shows that amoxicillin causes long-term gut dysbiosis and reduces type-17 immune tone in the lungs.

A large reverse-genetic screen identifies numerous regulators of testis nascent myotube collective cell migration and collective organ sculpting

The paper identifies 29 genes regulating testis morphogenesis through a reverse-genetic screen in Drosophila, revealing roles for dPix and its partners in collective cell migration and organ shaping.

DrugMap: A quantitative pan-cancer analysis of cysteine ligandability

DrugMap quantitatively analyzes cysteine ligandability across 416 cancer cell lines, revealing redox state, conformational changes, and mutations as drivers of variability, and identifies covalent inhibitors targeting NFκB1 and SOX10.