Author

Brian Timothy O'Neill

University of IowaORCID 0000-0002-5685-9805Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Gourav BhardwajiD· 2 shared Siming LiuiD· 2 shared Yumi ImaiiD· 2 shared Akansha Mishra· 1 shared Andrew S. GreenbergiD· 1 shared Brian D. FinkiD· 1 shared Christie M. Penniman· 1 shared Corinne E Bovee· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMolecular Biology

Gourav BhardwajORCID

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2 papers

Recent·Most cited

Perilipin 5 Phosphorylation is Dispensable for Upregulation of Hepatic Lipid Metabolism Genes upon Fasting but Required for Insulin Receptor Substrate 2 Expression in Male Mice

Corinne E Bovee, Ryan P Grandgenett, Michelle B. Trevino, Sucharita M. Dutta, Spencer J. Peachee, Shayla Kopriva, Farakh Haider, Siming Liu, Gourav Bhardwaj, Christie M. Penniman, Brian Timothy O'Neill, Yumi Imai

This study investigates the role of PLIN5 phosphorylation in mice, finding it dispensable for lipid metabolism gene upregulation during fasting but necessary for IRS2 expression in males.

Endocrinology · Apr 12, 2025Peer-reviewedMolecular Biology

Perilipin2 down-regulation in beta cells impairs insulin secretion under nutritional stress and damages mitochondria

Akansha Mishra, Siming Liu, Joseph A. Promes, Mikako Harata, William I. Sivitz, Brian D. Fink, Gourav Bhardwaj, Brian Timothy O'Neill, Kang Chen, Rajan Sah, Stefan Strack, Samuel B. Stephens, Timothy King, Laura Kate Jackson, Andrew S. Greenberg, , Yumi Imai

This study shows that reducing Perilipin2 in beta cells impairs insulin secretion and mitochondrial function under nutritional stress.

JCI Insight · Mar 30, 2021Peer-reviewedMolecular Biology