Rajan Sah

This study shows that microglial SWELL1 deficiency increases male-specific seizure severity but protects neurons through impaired phagocytosis and reduced neuroactive metabolite release.

This study identifies LRRC8C as a non-redundant component of the endothelial LRRC8 complex that regulates vascular reactivity and blood pressure.

This study shows that the lysosomal LRRC8 complex regulates lysosomal pH, morphology, and systemic glucose metabolism by affecting mTOR signaling and autophagic flux.

This study identifies LRRC8 complexes as ATP/ADP release channels in platelets that regulate thrombosis by modulating calcium and PI3K-AKT signaling through P2X1, P2Y1, and P2Y12 receptors.

This study shows that endothelial Piezo1 regulates vascular smooth muscle cell differentiation in zebrafish and mice by modulating klf2a levels and flow force sensing.

This study shows superoxide enters neurons directly through LRRC8A-containing volume-regulated anion channels, blocking oxidative stress and glutamate excitotoxicity.

This study shows that deleting LRRC8A in the brain reduces stroke damage without affecting glutamate release, challenging the idea that VRACs contribute to stroke via glutamate release.

This study shows that brain-specific deletion of LRRC8A in mice leads to early mortality due to seizures, astrogliosis, and amino acid neurotransmitter dysregulation.

This study shows that reducing Perilipin2 in beta cells impairs insulin secretion and mitochondrial function under nutritional stress.