Author

Spencer J. Peachee

University of IowaORCID 0009-0004-6147-0046Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Siming LiuiD· 3 shared Yumi ImaiiD· 3 shared Aidan Freshly· 2 shared ANAMIKA VIKRAM· 2 shared Claudia Jun· 2 shared Corinne E Bovee· 2 shared Farakh Haider· 2 shared Gianna SagonaiD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMolecular Biology

Siming LiuORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cell BiologyDiabetesPeer-reviewedMay 28, 2026

ALPHA/BETA HYDROLASE DOMAIN CONTAINING 5 SUPPORTS GLUCOSE-STIMULATED-LIPOLYSIS AND INSULIN SECRETION IN PANCREATIC BETA CELLS

Lucy Kim, Siming Liu, Spencer J. Peachee…·Yumi Imai

This study identifies ABHD5 as a critical co-activator of PNPLA2 in pancreatic beta cells, showing it supports glucose-stimulated lipolysis and insulin secretion.

DOI 10.2337/db25-1156

humanmouse

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Molecular BiologyEndocrinologyPeer-reviewedApr 12, 2025

Perilipin 5 Phosphorylation is Dispensable for Upregulation of Hepatic Lipid Metabolism Genes upon Fasting but Required for Insulin Receptor Substrate 2 Expression in Male Mice

Corinne E Bovee, Ryan P Grandgenett, Michelle B. Trevino…·Yumi Imai

This study investigates the role of PLIN5 phosphorylation in mice, finding it dispensable for lipid metabolism gene upregulation during fasting but necessary for IRS2 expression in males.

3 citations

mousebulk RNA-seq

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Molecular BiologybioRxivPreprintNov 17, 2024

Lipid droplet protein Perilipin 2 is critical for the regulation of insulin secretion through beta cell lipophagy and glucagon expression in pancreatic islets

Siming Liu, Israel J Wipf, Aditya Joglekar…·Yumi Imai

This study shows that PLIN2 regulates lipophagy in beta cells to prevent fatty acid accumulation in mitochondria, which impairs insulin secretion and mitochondrial function.

1 citation

humanexperimental assay

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