PARG activity is required for cell death by parthanatos
Rafael Dias de Moura, Beatriz Kopel, Priscilla Doria de Mattos, Penélope Ferreira Valente, Aline Costa Santos, Rafael Teixeira do Nascimento, Fernanda M. Prado, M. S. De Medeiros, João Carlos Setúbal, Nadja Cristhina de Souza-Pinto, Nícolas C. Hoch
This study identifies PARG activity as essential for parthanatos cell death, showing that both PAR formation and hydrolysis are required, and reveals a new PARG splice variant.
bioRxiv · May 14, 2026 · PreprintBiochemistry