Nícolas C. Hoch

This study identifies PARG activity as essential for parthanatos cell death, showing that both PAR formation and hydrolysis are required, and reveals a new PARG splice variant.

This study develops an RP-HPLC method with UV-Vis detection to simultaneously quantify multiple adenine nucleotides in mammalian cells, showing sensitivity and applicability in pharmacological studies.

This study identifies LINC00941 as a KRAS-regulated lncRNA that promotes aggressiveness and chemoresistance in pancreatic cancer, with prognostic significance.

The paper analyzes pituitary transcriptional dynamics in mouse models of congenital hypopituitarism across developmental stages, revealing distinct gene expression patterns and functional impairments in Prop1 mutants.

This paper shows that the SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling in human cells.