Akira Murakami

Biomechanical regulation of Ca2+ dynamics during muscle stem cell activation

This study examines Ca2+ dynamics in muscle stem cells during regeneration, finding increased fluctuations in activated cells mediated by mechanosensitive ion channels.

Identification of a transient receptor potential channel that is regulated by phospholipid asymmetry

The paper identifies TRPM8 as an ion channel regulated by phospholipid asymmetry and shows that cytoplasmic phosphatidylserine is required for its function.

Membrane dynamics-mediated heat retention dictates economical intracellular energy flow

This study experimentally demonstrates intracellular heat retention mediated by membrane dynamics, showing heat generated by metabolism is partially retained and used for efficient energy flow.

Baculovirus-mediated gene transfer enables functional expression of PIEZO1 ion channel in isolated muscle satellite cells

This study develops a baculovirus-mediated method to express PIEZO1 in muscle satellite cells, restoring their proliferative capacity and enabling functional studies of large proteins.

Expanding and Decoding the Chemistry of Phospholipid Headgroup in Eukaryotes

The paper develops a method to manipulate phospholipid headgroups and discovers their diverse biological effects across species.

Nobiletin, a Polymethoxyflavonoid, Activates the Desuccinylase Activity of SIRT5 and Prevents the Development of Heart Failure

This study shows nobiletin prevents heart failure by enhancing SIRT5 desuccinylase activity, which inhibits p300-HAT activity in mice.

The GPI-anchored Ly6 protein Belly roll regulates Drosophila melanogaster escape behaviors by modulating the excitability of nociceptive peptidergic interneurons

This study identifies Belly roll as a regulator of Drosophila escape behaviors by modulating neuronal activity in ABLK neurons.