Author

Kelly Astudillo

NYU Langone HealthORCID 0000-0002-5697-0968Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell type annotation· 1 Assay:CITE-seq· 1 Approach:experimental assay· 1

Frequent Co-Authors

Amanda AllaniD· 3 shared Towfique RajiD· 3 shared Aloysius DomingoiD· 2 shared Beomjin JangiD· 2 shared Casey YoungiD· 2 shared Daniele MatteiiD· 2 shared Deborah RaymondiD· 2 shared Elisa NavarroiD· 2 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Amanda AllanORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Peripheral Immune Alterations and T Cell Clonal Dynamics Across the Parkinson's Disease Spectrum

Mikaela R. Rosen, J. Oriol Narcis Majos, Daniele Mattei, Elena Mejia, Carlos Perez Mandry, Beomjin Jang, Kailash BP, Tatsuhiko Naito, Amanda Allan, Tarek Khashan, Charlie Argyrou, Mengxi Yang, Deborah Raymond, Casey Young, Kelly Astudillo, , Towfique Raj

This study uses single-cell RNA sequencing and TCR profiling to analyze immune changes in Parkinson's disease across different stages and identifies sex-dependent immune alterations and TCR diversity.

medRxiv · Sep 29, 2026 · PreprintGenetic & Genomic Medicine

Integrated Stress Response Signatures Drive Monocyte Dysfunction in GBA1- and LRRK2-Linked Parkinson's Disease

Daniele Mattei, Erica Brophy, Mikaela Rosén, Oriol Narcis Majos, Aloysius Domingo, Elena Meijia, Claudia De Sanctis, Beomjin Jang, Tarek Khashan, Mengxi Yang, Deborah Raymond, Casey Young, Jack Humphrey, Elisa Navarro, Amanda Allan, , Towfique Raj

The paper identifies integrated stress response (ISR) signatures and proteostasis defects in monocytes from GBA1- and LRRK2-linked Parkinson's disease, linking them to immune dysfunction.

medRxiv · Oct 8, 2025 · PreprintGenetic & Genomic Medicine

Transcriptome deregulation of peripheral monocytes in GBA-related Parkinson's disease

Giulietta Maria Riboldi, Ricardo A. Vialle, Elisa Navarro, Evan Udine, Kátia de Paiva Lopes, Jack Humphrey, Amanda Allan, Madison Parks, Brooklyn Henderson, Kelly Astudillo, Charalambos Argyrou, Maojuan Zhuang, Tamjeed Sikder, Josep Oriol Narcís, Shilpa Dilip Kumar, , Towfique Raj

The paper identifies transcriptomic changes in monocytes from GBA mutation carriers with Parkinson's disease, highlighting dysregulated pathways related to alpha-synuclein degradation and lysosomal function.

Molecular Neurodegeneration · Aug 17, 2022Peer-reviewedGenetic & Genomic Medicine