Chenggang Wu

This study shows AI-2 production in Fusobacterium nucleatum is subspecies-specific and not linked to quorum sensing.

This study shows that the oda gene, which encodes ornithine decarboxylase for putrescine biosynthesis, is essential for the viability of Fusobacterium nucleatum under anaerobic conditions.

This study identifies Fusobacterium nucleatum-produced indole metabolites that activate the AHR-TERT axis, promoting CRC cell proliferation and revealing FTIN as a potential biomarker.

This paper shows that disrupting the Rnf complex in Fusobacterium nucleatum reduces FadA amyloid formation and tumor development by affecting signal peptidase expression.

This study identifies the CarSR two-component system as a direct regulator of radD in Fusobacterium nucleatum, revealing its role in sensing coaggregation and regulating adhesion.

This paper develops a conditional plasmid system for gene deletion in non-model Fusobacterium nucleatum strains, successfully generating mutants in multiple subspecies and related species.

This paper develops a SacB-based counterselection method for efficient allelic exchange in Fusobacterium nucleatum, enabling unmarked gene mutations without requiring a modified host.

This study identifies a bacterial P-type ATPase transporter, PtaT, that specifically binds and mediates the uptake of host-derived tsRNAs in Fusobacterium nucleatum.