Chang Liu

Linking clinical border morphology to cell-scale growth mechanisms in melanoma: a segmentation-to-simulation alignment study

Across 1,581 ISIC 2018 lesions, melanoma borders differ from nevi mainly by coarse lobulation rather than fractal dimension; of six simulated mechanisms, only an imposed long-range growth-rate field reproduces this.

An Asynchronous Production Line of Meiotic Prophase I in the Mouse Fetal Ovary

The paper challenges the notion of synchronous meiosis initiation in mouse fetal ovaries, showing asynchronous entry and progression from E12.5 to E16.5, supported by a predictive meiotic clock model.

A negative feedback model to explain regulation of SARS-CoV-2 replication and transcription

The paper proposes a negative feedback model explaining SARS-CoV-2 replication and transcription regulation through nsp15 cleavage of transcription regulatory sequences.

Complemented palindrome small RNAs first discovered from SARS coronavirus

The paper discovers complemented palindrome small RNAs (cpsRNAs) from SARS coronavirus and shows they can induce cell apoptosis, suggesting a role in viral pathogenicity.