Ze Chen

This study shows that lymph nodes actively drive melanoma evolution and immune evasion, linking regional metastasis to poor patient outcomes.

conMItion adjusts confounding factors in multi-omics data to improve association measurements, identifying cancer-related genes and cell type associations in bladder and lung cancer.

This study shows that aneuploidy promotes ROS resistance by suppressing PARP1, which enhances metastasis, and identifies CEBPB as a key mediator of this process.

The paper uses small RNA sequencing to obtain the full-length genome sequence of a novel tick-borne flavivirus and demonstrates the feasibility of using sRNA-seq for virus detection in low-RNA samples.

The paper annotates tick mitochondrial genomes using long-PCR and NGS, revealing novel STR variation and a transposon-like element, and links STR mutations to aging and disease.

The paper annotates mitochondrial genomes of human, chimpanzee, rhesus macaque, and mouse using 5' and 3' end small RNAs at 1 base-pair resolution, revealing novel functions and conserved sequence blocks.

This study uses sRNA-seq to annotate the mitochondrial genome of Erthesina fullo at 1 bp resolution, revealing new insights into tandem repeats and steady-state lncRNAs.

This study uses pan RNA-seq to show the widespread presence of 5' and 3' end small RNAs, which can annotate mitochondrial and nuclear non-coding genes and identify new steady-state RNAs, challenging classical theories.

The study detects a 235-bp DNA segment from African Swine Fever Virus in hard ticks from sheep and bovine, showing 99% identity with ASFV and suggesting a new strain.

The paper discovers complemented palindrome small RNAs (cpsRNAs) from SARS coronavirus and shows they can induce cell apoptosis, suggesting a role in viral pathogenicity.