Shan Gao

This study uses machine learning to distinguish rare disease cases from controls using observed and excluded phenotypes, finding that Random Forest performs best and both specificity and occurrence count are important for feature selection.

The paper identifies coordinate up-regulation of TK1 and TS in cycling cells and shows it is essential for dTTP supply, supporting dual-targeted cancer therapy.

This study discovers a Notch/snRNA negative feedback regulation, linking cell signaling to RNA splicing and offering therapeutic implications for Alzheimer's disease.

The paper precisely annotates Drosophila mitochondrial genomes, identifies conserved polyA motifs in control regions, and provides a high-quality D. simulans mt genome.

The paper proposes a two-route model for SARS-CoV-2 RTC function in jumping transcription, identifies a motif for METTL3 recognition, and reports TRS hairpins for NSP15 cleavage and RNA methylation.

The paper reports the full-length genome of O. polymorpha HU-11/CBS4732, revealing large duplicated segments in subtelomeric regions and structural variations between CBS4732 and NCYC495.

The paper proposes a negative feedback model explaining SARS-CoV-2 replication and transcription regulation through nsp15 cleavage of transcription regulatory sequences.

The paper uses small RNA sequencing to obtain the full-length genome sequence of a novel tick-borne flavivirus and demonstrates the feasibility of using sRNA-seq for virus detection in low-RNA samples.

The paper annotates tick mitochondrial genomes using long-PCR and NGS, revealing novel STR variation and a transposon-like element, and links STR mutations to aging and disease.

The paper annotates mitochondrial genomes of human, chimpanzee, rhesus macaque, and mouse using 5' and 3' end small RNAs at 1 base-pair resolution, revealing novel functions and conserved sequence blocks.

NormExpression evaluates normalization methods using AUCVC and mSCC metrics, showing consistency across bulk and scRNA-seq data, and provides an R package for method comparison.

This study uses sRNA-seq to annotate the mitochondrial genome of Erthesina fullo at 1 bp resolution, revealing new insights into tandem repeats and steady-state lncRNAs.

This study uses pan RNA-seq to show the widespread presence of 5' and 3' end small RNAs, which can annotate mitochondrial and nuclear non-coding genes and identify new steady-state RNAs, challenging classical theories.

The paper discovers complemented palindrome small RNAs (cpsRNAs) from SARS coronavirus and shows they can induce cell apoptosis, suggesting a role in viral pathogenicity.

The paper uses PacBio full-length transcriptome data to discover two novel lncRNAs in human mitochondrial DNA and propose a new class of lncRNAs called ltiRNAs.