Thomas Knöpfel

Psychedelic 5-HT2A agonist increases spontaneous and evoked 5-Hz oscillations in visual and retrosplenial cortex

This study shows that a 5-HT2A agonist increases 5-Hz oscillations in visual and retrosplenial cortex, suggesting enhanced top-down control of perception.

Lasting effect of psilocybin on sociability can be blocked by DNA methyltransferase inhibition

The paper shows psilocybin promotes lasting social behavior in autism models, which is reversed by DNA methyltransferase inhibition.

Inhibition is a prevalent mode of activity in the neocortex around awake hippocampal ripples

The paper investigates neocortical activity during hippocampal ripples in awake mice, finding that deactivation and activation dominate post-ripple activity, with distinct subpopulations of neurons showing opposing firing rate changes.

Hippocampal gamma and sharp wave/ripples mediate bidirectional interactions with cortical networks during sleep

This study investigates cortico-hippocampal interactions during sleep using voltage imaging and electrocorticography, finding bidirectional exchanges mediated by hippocampal slow gamma and ripples.

Bright near-infrared genetically encoded voltage indicator for all-optical electrophysiology

The paper develops a bright near-infrared genetically encoded voltage indicator (nirButterfly) for all-optical electrophysiology, enabling improved voltage imaging combined with optogenetic activation.

Psilocybin rescues sociability deficits in an animal model of autism

This study shows psilocybin improves social behavior in a prenatal valproic acid-induced ASD mouse model.

Subcellular resolution 3D light field imaging with genetically encoded voltage indicators

This study demonstrates sub-cellular resolution 3D light field imaging of voltage signals in acute mouse brain slices using genetically encoded voltage indicators.