Single-cell atlas of the fetal Down syndrome cortex uncovers chromosome 21 regulators of intellectual disability gene networks
Michael Lattke, Wee Leng Tan, Salil Kalarikkal Sukumaran, Kagistia Hana Utami, Marcos Sintes, Srinivasan Sakthivel, Jonathan Tan, Auriel Theodora Jacobea Lim, Vibhavari Aysha Bansal, Katerina Rekopoulou, Nik Matthews, Ivan Alić, Željka Krsnik, Dean Nižetić, Boaz P. Levi, Vincenzo De Paola
The paper constructs a single-cell atlas of fetal Down syndrome cortex, identifying chromosome 21 transcription factors that regulate intellectual disability gene networks and showing their normalization can restore molecular signatures.
bioRxiv · Dec 30, 2025 · PreprintNeuroscience