Intraperitoneal programming of tailored CAR macrophages via mRNA-LNP to boost cancer immunotherapy
Kedan Gu, Ting Liang, Luting Hu…·Weihong Tan
This study develops an mRNA-LNP delivery system to program CAR-Ms in vivo, showing enhanced antitumor effects through immune activation and synergy with PD-1/L1 therapy.