Multi-omic rejuvenation of human cells by maturation phase transient reprogramming
Diljeet Gill, Aled Parry, Fátima Santos…·Wolf Reik
This paper introduces a method to rejuvenate human fibroblasts by transient reprogramming to the maturation phase of iPSCs, followed by recovery of fibroblast identity, resulting in significant rejuvenation of transcriptome, epigenome, and functional markers.