Brendan Evano

This study uses live imaging to show that Duchenne Muscular Dystrophy mouse model MuSCs have impaired migration and premature differentiation due to altered signaling pathways, with intrinsic and extracellular factors influencing their behavior.

The paper identifies distinct molecular and functional properties of extraocular muscle stem cells compared to limb muscle stem cells using scRNA-seq and other methods.

This study identifies molecular differences between extraocular and limb muscle stem cells, showing that EOM MuSCs reprogram their transcriptome and epigenome after transplantation, with some genes resisting engraftment.

This study shows that ageing increases transcriptional heterogeneity and DNA methylation drift in muscle stem cells, disrupting transcriptional networks and stem cell function.