Shahragim Tajbakhsh

This paper introduces a dual-gastruloid model to study the co-development of foregut-pharyngeal mesoderm in mice, showing the role of Foxa2 in Tbx1 expression.

This study identifies AR-dependent Mybph repression as a mechanism contributing to skeletal muscle sexual dimorphism using ChIL-seq and an AirID-AR knock-in mouse.

This study uses live imaging to show that Duchenne Muscular Dystrophy mouse model MuSCs have impaired migration and premature differentiation due to altered signaling pathways, with intrinsic and extracellular factors influencing their behavior.

This study reconstructs the mesodermal origins of neck muscles in vertebrates, showing that neck evolution arose from pre-existing muscle groups in fishes through developmental expansion.

The paper identifies distinct molecular and functional properties of extraocular muscle stem cells compared to limb muscle stem cells using scRNA-seq and other methods.

The paper identifies Myf5+ bipotent progenitors in mice that generate both muscle and connective tissue, showing their distinct lineage and regulatory features.

The paper investigates the development of extraocular muscles, identifying retinoic acid's role in their formation and tendon attachment sites.

This study identifies molecular differences between extraocular and limb muscle stem cells, showing that EOM MuSCs reprogram their transcriptome and epigenome after transplantation, with some genes resisting engraftment.

The paper identifies a fibroblast-to-myoblast conversion driven by BMP signalling at the muscle-tendon interface during limb development.

This study shows that ageing increases transcriptional heterogeneity and DNA methylation drift in muscle stem cells, disrupting transcriptional networks and stem cell function.

The paper identifies a genetic hierarchy involving Tbx1, Isl1, and Met/HGF signaling that regulates antero-posterior patterning of esophagus striated muscle in mice.

This study identifies unique genetic programs for neck muscles and connective tissues in mammals using a 3D model and lineage analysis in mice.

This study develops an in vitro protocol to recapitulate early paraxial mesoderm development in mouse ES cells, showing efficient differentiation into muscle precursor cells and functional muscle fibers.