Koen Kole

Neuromodulatory Control of Cortical Function: Cell-Type Specific Regulation of Neuronal Information Transfer

This study investigates how neuromodulators like dopamine and acetylcholine regulate neuronal information transfer by altering functional domains in excitatory and inhibitory neurons.

Robust activity-dependent mitochondrial calcium dynamics at the AIS is dispensable for action potential generation

The paper investigates the role of mitochondrial calcium dynamics at the axon initial segment (AIS) in action potential generation and finds they are dispensable for this function.

Parvalbumin basket cell myelination accumulates axonal mitochondria to internodes

The paper investigates mitochondrial clustering in myelinated segments of PV+ basket cell axons and shows that demyelination affects mitochondrial distribution while noncompacted myelin preserves clustering.

A whole-cell recording database of neuromodulatory action in the adult neocortex

The paper introduces a database of whole-cell patch-clamp recordings from adult mouse neocortical neurons, examining the effects of various neuromodulators on cellular excitability.

Assessing the utility of MAGNETO to control neuronal excitability in the somatosensory cortex

This study evaluates MAGNETO's ability to control neuronal excitability in the somatosensory cortex using in vitro and in vivo recordings, finding no effect on subthreshold membrane excitability or action potential generation.

A databank for intracellular electrophysiological mapping of the adult somatosensory cortex

The paper provides a database of intracellular electrophysiological recordings from adult mouse somatosensory cortex neurons to study neuronal integration and action potential generation.

Neocortical microdissection at columnar and laminar resolution for molecular interrogation

This paper introduces a microdissection technique for isolating neocortical columns and laminae from mouse brains, enabling high-resolution molecular analysis.

Cellular diversity of the somatosensory cortical map plasticity

This study identifies molecular correlates of experience-dependent map plasticity in the barrel cortex by analyzing transcriptional and translational changes during altered whisker use.