Tansu Celikel

Neuromodulatory Control of Cortical Function: Cell-Type Specific Regulation of Neuronal Information Transfer

This study investigates how neuromodulators like dopamine and acetylcholine regulate neuronal information transfer by altering functional domains in excitatory and inhibitory neurons.

Evolutionarily Optimized Network Topology as a Structural Prior for Data-Efficient Sparse Neural Classification

The paper tests if evolutionarily optimized network topologies can improve data efficiency in neural classifiers, finding that biologically derived sparse networks outperform synthetic alternatives with similar sparsity.

Neuronal Identity is Not Static: An Input-Driven Perspective

The paper shows neuronal classification is dynamic, not static, by demonstrating input patterns significantly influence functional classification in mice cortical neurons.

From Skin to Cortex: End-to-End Spiking Neural Network Simulation of Tactile Information Flow

This paper presents an end-to-end spiking neural network model of the tactile pathway from mechanoreceptors to cortex, showing efficient tactile information encoding and transformation.

Decoupling synaptic weight and connection sparsity reveals asymmetriccontrol of network dynamics

The paper examines how synaptic weight and connection probability influence network dynamics in a thalamocortical microcircuit model, identifying four organizing principles of population activity.

Information transfer and recovery for the sense of touch

The paper shows that sensory information is accurately represented in somatic PSPs but lost during AP generation, yet can be recovered in local populations to maintain high-fidelity touch processing.

NeuroCarta: An Automated and Quantitative Approach to Mapping Cellular Networks in the Mouse Brain

NeuroCarta is an open-source MATLAB toolbox that constructs and analyzes brain-wide connectivity networks using the Allen Mouse Brain Connectivity Atlas, revealing a densely connected mouse brain with regional projection variations.

Electrical diversity of neurons in sensory cortices

The paper introduces a method to objectively select informative parameters for neuronal functional classification, revealing 9 and 11 subpopulations in somatosensory and visual cortices respectively.

Where top-down meets bottom-up: Cell-type specific connectivity map of the whisker system

The paper updates the mouse whisker system connectivity map by identifying new monosynaptic connections and creating the first cell-type-specific map of the network.

The tuning of tuning: how adaptation influences single cell information transfer.

The paper measures and models how intrinsic neural properties affect information transfer in cortical neurons, finding excitatory neurons have more heterogeneous and lossy information transfer than inhibitory neurons.

Nonlinear super-resolution signal processing allows intracellular tracking of calcium dynamics

This paper introduces ARES, a baseline-free method for quantifying fluorescence signals that improves spatiotemporal resolution of calcium imaging data and enables tracking of intracellular calcium dynamics.

Cortical representation of touch in silico

The paper introduces an in silico model of the somatosensory cortex that replicates touch representations and synaptic changes from whisker deprivation.

NETSCOPE: Information-Theory Based Network Discovery and Analysis

NETSCOPE infers and analyzes biological networks using information-theoretic methods, validated on synthetic and real data across multiple domains.

Electrochemical Detection of Adrenaline and Hydrogen Peroxide on Carbon Nanotube Electrodes

This paper develops carbon nanotube-coated electrodes for electrochemical detection of adrenaline and hydrogen peroxide, showing improved sensitivity and reduced overpotentials compared to graphite.

A whole-cell recording database of neuromodulatory action in the adult neocortex

The paper introduces a database of whole-cell patch-clamp recordings from adult mouse neocortical neurons, examining the effects of various neuromodulators on cellular excitability.

Assessing the utility of MAGNETO to control neuronal excitability in the somatosensory cortex

This study evaluates MAGNETO's ability to control neuronal excitability in the somatosensory cortex using in vitro and in vivo recordings, finding no effect on subthreshold membrane excitability or action potential generation.

Serotonergic development of active sensing

This study shows that altered serotonergic signaling during early postnatal development impairs adult sensorimotor control in rats.

Development of adaptive motor control for tactile navigation

This study shows that adaptive motor control of whisker position in rats matures after the third postnatal week, while body-based navigation develops earlier.

PASER for automated analysis of neural signals recorded in pulsating magnetic fields

PASER is a MATLAB-based toolbox for automated analysis of neural recordings in magnetic fields, offering denoising, artefact removal, and spike sorting with integrated evaluation of algorithms.

Real-time contextual feedback for closed-loop control of navigation

The paper introduces PolyTouch, a software for real-time animal behavior tracking and closed-loop feedback, demonstrating its ability to condition mice to avoid virtual targets through auditory feedback.

A databank for intracellular electrophysiological mapping of the adult somatosensory cortex

The paper provides a database of intracellular electrophysiological recordings from adult mouse somatosensory cortex neurons to study neuronal integration and action potential generation.

Neocortical microdissection at columnar and laminar resolution for molecular interrogation

This paper introduces a microdissection technique for isolating neocortical columns and laminae from mouse brains, enabling high-resolution molecular analysis.

Cellular diversity of the somatosensory cortical map plasticity

This study identifies molecular correlates of experience-dependent map plasticity in the barrel cortex by analyzing transcriptional and translational changes during altered whisker use.