Author

Stefan D. Gentile

Broad InstituteORCID 0000-0002-5759-7157Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Alan C. MulleniD· 2 shared Amel Ben SaadiD· 2 shared Anil K. ChandrakeriD· 1 shared Anja HessiD· 1 shared Arden Weilheimer· 1 shared Benjamin J. Toles· 1 shared Daniel Stephan PrattiD· 1 shared Nahid Arghiani· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCell Biology

Alan C. MullenORCID

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2 papers

Recent·Most cited

Cell BiologyHepatology CommunicationsPeer-reviewedSep 16, 2026

Prime Editing Models the MTARC1 A165T Variant in Human Liver Organoids, Demonstrating Reduced Steatosis, Inflammation, and Fibrosis

Amel Ben Saad, Nahid Arghiani, Arden Weilheimer…·Alan C. Mullen

This study models the MTARC1 A165T variant in human liver organoids, showing reduced steatosis, inflammation, and fibrosis compared to reference sequence organoids.

DOI 10.1097/hc9.0000000000001022

humanorganoid / primary culture

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Molecular BiologyThe EMBO JournalPeer-reviewedNov 14, 2023

Single cell transcriptomic landscapes of human liver organoids stratify models of non-alcoholic fatty liver disease

Anja Hess, Stefan D. Gentile, Amel Ben Saad…·Alan C. Mullen

The paper evaluates three NAFLD liver organoid models using single-cell transcriptomics, finding TGF-β1 induces fibrosis while OA reduces fibrotic signatures.

53 citationstop 1%

humanscRNA-seq

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