Alan C. Mullen

This study models the MTARC1 A165T variant in human liver organoids, showing reduced steatosis, inflammation, and fibrosis compared to reference sequence organoids.

The paper integrates multiple datasets to create a comprehensive human liver cell atlas, identifying new cell types and associations with demographic factors.

This study uses single-cell RNA sequencing to analyze how sex and age affect gene expression and cellular interactions in healthy human liver cells.

Singletrome enhances scRNA-seq analysis by integrating lncRNA annotations, improving mapping specificity and enabling lncRNA-based cell type clustering and disease prediction.

This study shows diet-induced thermogenesis reduces adiposity and protects against liver disease in male mice, with UCP1 playing a key role in BAT and non-adipocyte cells.

The paper uses spatial transcriptomics to map cell types and their spatial organization in healthy and fibrotic human liver, identifying changes in hepatocyte populations during fibrosis.

This study identifies an HIV-1 antisense transcript that enforces latency by inducing epigenetic silencing and blocks latency reversal in CD4+ T-cells.

The paper evaluates three NAFLD liver organoid models using single-cell transcriptomics, finding TGF-β1 induces fibrosis while OA reduces fibrotic signatures.

The paper identifies novel coding and noncoding transcripts in human hepatic stellate cells and links them to liver fibrosis, suggesting potential therapeutic targets and biomarkers.

This study shows that lncRNA DIGIT and BRD3 form phase-separated condensates to regulate endoderm differentiation by interacting with H3K18ac regions.

The paper identifies and characterizes m6A methylated circular RNAs, showing cell-type specificity and cross-talk with m6A-mRNAs through YTHDF2.