Sreedharan Sajikumar

Primate Hippocampus Reveals Distinct Rules for Associative Synaptic Plasticity

The paper examines synaptic plasticity in nonhuman primates, finding that theta-burst stimulation induces LTP with a lower threshold for synaptic tagging and capture compared to rodents.

D1/D5 Receptor Activation Promotes Long-Term Potentiation and Synaptic Tagging/Capture in Hippocampal Area CA2

This study shows that D1/D5 receptor activation primes hippocampal CA2 synaptic plasticity through NMDAR and protein synthesis-dependent mechanisms, linking dopamine signaling to social memory.

Metaplastic reinforcement of long-term potentiation in rat hippocampal area CA2 by cholinergic receptor activation

This paper shows that cholinergic receptor activation in rat hippocampal CA2 induces long-term depression that can switch to long-term potentiation, demonstrating metaplasticity in synaptic plasticity.

LOCAL REGULATION AND FUNCTION OF IMPORTIN-BETA 1 IN HIPPOCAMPAL NEURONS DURING TRANSCRIPTION-DEPENDENT PLASTICITY

This study shows importin-β1's role in nuclear import of soluble proteins during synaptic activity and long-term plasticity in hippocampal neurons.

Inactive variants of death receptor p75NTR reduce Alzheimer's neuropathology by interfering with APP internalization

The paper shows that inactive p75NTR variants reduce Alzheimer's neuropathology by decreasing APP internalization and amyloidogenic processing in 5xFAD mice.