Author

Itziar Pinilla‐Macua

University of PittsburghORCID 0000-0002-5787-3764Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Alexander D. SorkiniD· 3 shared Christopher M. FurchtiD· 1 shared Frederick CoheniD· 1 shared João A. PauloiD· 1 shared Matthew J. LazzaraiD· 1 shared Paul J. MyersiD· 1 shared Ratul MukerjiiD· 1 shared Rushikesh Deshpande· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersCell Biology

Alexander D. SorkinORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Traffickome infers directed, compartment-resolved membrane trafficking from proteomic data

Rushikesh Deshpande, Itziar Pinilla‐Macua, João A. Paulo, Steven P. Gygi, Alexander D. Sorkin

Traffickome infers directed membrane trafficking between cellular compartments from proteomic data, achieving high accuracy in predicting trafficking transitions.

bioRxiv · Sep 22, 2026 · PreprintCell Biology

Small-molecule CBLB inhibitor abolishes EGFR ubiquitination, reduces receptor endocytosis and diminishes cell motility signaling

Itziar Pinilla‐Macua, Ratul Mukerji, Frederick Cohen, Alexander D. Sorkin

The paper uses a CBLB inhibitor to show that EGFR ubiquitination is essential for clathrin-mediated endocytosis and cell motility, but not for other downstream signaling pathways.

Proceedings of the National Academy of Sciences · Mar 27, 2026Peer-reviewedCell Biology

A spatially resolved EGFR signaling model predicts the length scale of GAB1-SHP2 complex persistence

Paul J. Myers, Christopher M. Furcht, Itziar Pinilla‐Macua, Alexander D. Sorkin, William M. Deen, Matthew J. Lazzara

The paper develops a reaction-diffusion model to predict the spatial persistence of GAB1-SHP2 complexes downstream of EGFR activation and validates it with experiments.

bioRxiv · Nov 8, 2021 · PreprintSystems Biology