Joël Küchler

This paper introduces a microfluidic platform to study neurodegeneration in human neural circuits, identifying early electrophysiological biomarkers of disease progression.

The paper develops an in vitro platform with biophysical modeling to study synaptic transmission in isolated human neuronal pairs, revealing receptor-specific changes in long-term potentiation.

MyeliMAP models human CNS myelination using hPSC-derived neurons and oligodendrocytes in a microfluidic platform, showing enhanced action potential conduction and stabilized network activity.

This paper demonstrates in vitro neuronal networks capable of performing Boolean computations like NAND and OR using controlled topology and extracellular stimulation.

This study investigates how microchannel width and spatial constraints affect axon growth in brain-on-chip systems, finding that restrictions smaller than 350nm prevent axon penetration.

This paper describes a method to engineer biological neural networks on high-density CMOS microelectrode arrays to improve spatial resolution and axon guidance.