Computational Rational Design of Larger AAV Icosahedral Capsids
This paper designs a larger AAV capsid with T=3 symmetry using AI, increasing its cargo capacity to up to 35 kb.
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University of MiamiORCID 0000-0002-5817-4914Unclaimed ORCID profile · follow to get notified of new preprints
10 papers
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This paper designs a larger AAV capsid with T=3 symmetry using AI, increasing its cargo capacity to up to 35 kb.
Jordan R. Walker, Natascha S. Varona, Bailey A. Wallace…·Cynthia B. Silveira
The paper investigates abundance-activity decoupling in sulfur-cycling bacteria in meromictic lakes, linking it to viral infection types and geochemical conditions.
Paul C. Kirchberger, Antoni Luque
The paper identifies a novel group of circular mobile genetic elements in marine environments, resembling viruses but lacking typical viral markers, and suggests they may function as virus-like elements.
Abelardo Aguilar-Cámara, Ingrid Miranda, Omer Nadel…·Antoni Luque
The paper investigates the evolutionary relationship between HK97-fold viruses and encapsulins, finding bidirectional transitions through procapsids.
Colin Brown, Anuradha Agarwal, Antoni Luque
pyCapsid is a Python package that analyzes protein shells to identify dynamics and quasi-rigid mechanical units, generating interpretable reports and visualizations.
Jennifer M. Podgorski, Joshua Podgorski, Lawrence Abad…·Simon J. White
The paper identifies a novel capsid stabilization mechanism in bacteriophages that allows larger genomes to be packaged without changing capsid size, offering insights for gene delivery system engineering.
R. A. Edwards, Elizabeth Ann Dinsdale, Anca Mara Segall…·Bhavya Nalagampalli Papudeshi
This study isolates and characterizes three novel Crassvirales phages infecting Bacteroides cellulosilyticus WH2, revealing they do not co-evolve with their hosts and share a conserved tail spike protein involved in host interaction.
Jody C. McKerral, Bhavya Nalagampalli Papudeshi, Laura K. Inglis…·Robert Alan Edwards
The paper quantifies the benefits and costs of prophages in bacterial genomes, showing uniform prophage density and estimating their energetic contribution.
Cynthia B. Silveira, Ty N. F. Roach, Helena Villela…·Forest Rohwer
The paper investigates how oxygen loss from fleshy macroalgae leads to microbialization of coral reefs by increasing DOC:O2 ratios, promoting bacterial biomass accumulation.
Emma E. George, James Mullinix, Fanwei Meng…·Antoni Luque
This study examines how coral geometry, including fractal dimension, surface area, and perimeter, influences outcomes in coral-algal competition, finding that geometric features explain a significant portion of variability in winning and losing regions.