Simon J. White

Small viruses reveal bidirectional evolution between HK97-fold viruses and encapsulins via procapsids

The paper investigates the evolutionary relationship between HK97-fold viruses and encapsulins, finding bidirectional transitions through procapsids.

A novel method for predicting Lp(a) levels from routine outpatient genomic testing identifies those at risk of cardiovascular disease across a diverse cohort

This paper develops a method to predict Lp(a) levels from genomic data, combining SNV risk scores and KIV-2 repeat counts, and shows it improves risk prediction for cardiovascular disease in diverse populations.

A novel stabilization mechanism accommodating genome length variation in evolutionarily related viral capsids

The paper identifies a novel capsid stabilization mechanism in bacteriophages that allows larger genomes to be packaged without changing capsid size, offering insights for gene delivery system engineering.

Using symptom-based case predictions to identify host genetic factors that contribute to COVID-19 susceptibility

The paper uses symptom-based case predictions to conduct a GWAS on COVID-19, finding new genetic susceptibility insights and suggesting different genetic architectures for severity and susceptibility.

RNA X-ray footprinting reveals the consequences of an in vivo acquired determinant of viral infectivity

The paper uses X-ray footprinting to determine the secondary structures of bacteriophage MS2 RNA in different states, revealing packaging signals and the impact of the Maturation Protein on RNA conformation and capsid structure.

Atlas-CNV: a validated approach to call Single-Exon CNVs in the eMERGESeq gene panel

Atlas-CNV identifies single-exon CNVs in targeted sequencing data with reduced false discovery rate using C-scores and ExonQC thresholds.

Quality Control and Integration of Genotypes from Two Calling Pipelines for Whole Genome Sequence Data in the Alzheimer’s Disease Sequencing Project

The paper describes the quality control and integration of genotype calls from two pipelines for whole genome sequencing data in the Alzheimer’s Disease Sequencing Project, resulting in a high-quality consensus dataset.