Mark E. Fornace

This paper introduces transfer matrix and tensor models for nucleic acid secondary structure thermodynamics, achieving higher accuracy with fewer parameters and improved computational efficiency.

The paper develops mixed-material models and dynamic programming algorithms for analyzing equilibrium base-pairing properties of nucleic acid systems containing RNA, DNA, and 2'OMe-RNA strands.

This paper introduces third-generation in situ HCR with automatic background suppression, enabling multiplexed, quantitative mRNA imaging and flow cytometry with improved performance and ease-of-use.