Author

Samuel J. Schulte

California Institute of TechnologyORCID 0000-0001-9982-6504Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Bioinformatics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:imaging· 2 Organism:mouse· 2 Research Focus:spatial domain detection· 2 Assay:spatial transcriptomics· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Niles A. PierceiD· 4 shared Mark E. FornaceiD· 2 shared Avinash NanjundiahiD· 1 shared Boyoung ShiniD· 1 shared Ellen V. RothenbergiD· 1 shared Grace Ji-eun ShiniD· 1 shared Harry M. T. ChoiiD· 1 shared John K. HalliD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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4 shared papersDevelopmental Biology

Niles A. PierceORCID

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4 papers

Recent·Most cited

BioinformaticsACS Synthetic BiologyPeer-reviewedJan 7, 2026

Models and Algorithms for Equilibrium Analysis of Mixed-Material Nucleic Acid Systems

Avinash Nanjundiah, Mark E. Fornace, Samuel J. Schulte, Niles A. Pierce

The paper develops mixed-material models and dynamic programming algorithms for analyzing equilibrium base-pairing properties of nucleic acid systems containing RNA, DNA, and 2'OMe-RNA strands.

1 citation

DNA methylationChIP-seq

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Developmental BiologyDevelopmentPeer-reviewedFeb 15, 2024

HCR spectral imaging: 10-plex, quantitative, high-resolution RNA and protein imaging in highly autofluorescent samples

Samuel J. Schulte, Mark E. Fornace, John K. Hall…·Niles A. Pierce

32 citationstop 4%

zebrafishmouse

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Molecular BiologyACS Chemical BiologyPeer-reviewedJan 17, 2024

Multiplex, quantitative, high-resolution imaging of protein:protein complexes via hybridization chain reaction

Samuel J. Schulte, Boyoung Shin, Ellen V. Rothenberg, Niles A. Pierce

This paper develops a method to image protein:protein complexes with high resolution and quantitation using hybridization chain reaction, demonstrating its effectiveness in various biological samples.

16 citations

humanmouse

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Developmental BiologyDevelopmentPeer-reviewedNov 15, 2021

Hybridization chain reaction enables a unified approach to multiplexed, quantitative, high-resolution immunohistochemistry and in situ hybridization

Maayan Schwarzkopf, Mike C. Liu, Samuel J. Schulte…·Niles A. Pierce

This paper introduces a method using hybridization chain reaction for multiplexed, quantitative, high-resolution imaging of both proteins and RNA in challenging tissues.

118 citationstop 4%

spatial transcriptomicsimaging

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