Amanda K. Casey

This study identifies geranyl- and farnesyl-pyrophosphate as FicD inhibitors that differentially affect disease-causing variants, providing insights for therapeutic targeting of UPR.

This study shows that a mutation in FicD causes diabetes by disrupting BiP AMPylation and pancreatic endocrine homeostasis in mice.

This study investigates the role of FicD in regulating BiP AMPylation and UPR signaling in mouse embryonic fibroblasts under different stress conditions, revealing its impact on stress recovery and protein secretion.

This study shows FicD regulates UPR responses in the murine liver during mild stress but not chronic or acute UPR induction.

The paper identifies GCNA as a conserved regulator of genome stability in germ cells across species, showing its role in preventing DNA damage and maintaining fertility.

This study shows that Fic-mediated AMPylation of BiP is essential for photoreceptors to adapt to light stress in Drosophila.