Author
Howard Hughes Medical InstituteORCID 0000-0002-0678-7620Unclaimed ORCID profile · follow to get notified of new preprints
10 papers
Recent·Most cited
Nalleli Payne, Kelly A. Servage, Kim Orth, Jessie Fernandez, Wei Peng
The paper identifies AvrC as a rhamnosyltransferase with broad substrate specificity, showing it can modify plant proteins like RIN4, COPE1, and COPZ1.
bioRxiv · Aug 27, 2026 · PreprintBiochemistry
Yayun Zheng, Chenglong.Sun Sun, Sukhithasri Vijayrajratnam, Jananee Jaishankar, Lisa N. Kinch, Zhijian J. Chen, Kim Orth
This study identifies metabolic reprogramming and immune signaling modulation by Vibrio parahaemolyticus during host cell invasion and infection.
bioRxiv · Aug 20, 2026 · PreprintMicrobiology
Aubrie Blevins, Wei Peng, Lisa N. Kinch, Zihan Monshad, Andrea G. Paredes, Christina Volz, Jared P. Rutter, Amanda K. Casey, Kevin G. Hicks, Kim Orth
This study identifies geranyl- and farnesyl-pyrophosphate as FicD inhibitors that differentially affect disease-causing variants, providing insights for therapeutic targeting of UPR.
Proceedings of the National Academy of Sciences · Mar 4, 2026Peer-reviewedBiochemistry
Amanda K. Casey, Nathan M. Stewart, Naqi Zaidi, Hillery Fields Gray, Hazel A. Fields, Masahiro Sakurai, Carlos A. Pinzón-Arteaga, Bret M. Evers, Jun Wu, Kim Orth
This study shows that a mutation in FicD causes diabetes by disrupting BiP AMPylation and pancreatic endocrine homeostasis in mice.
Molecular Metabolism · Mar 10, 2025Peer-reviewedPhysiology
Jungyeon Kim, Jing Zhang, Lisa N. Kinch, Jinhui Shen, Sydney Field, Shahanshah Khan, Jan‐Michael Axel Klapproth, Kevin J. Forsberg, Tamia A. Harris-Tryon, K. A. Orth, Qian Cong, Josephine Ni
This study identifies genetic factors associated with invasiveness in Escherichia coli strains from IBD patients using whole genome sequencing and a modified invasion assay.
Cellular and Molecular Gastroenterology and Hepatology · Dec 27, 2024Peer-reviewedMicrobiology
Burak Gulen, Aubrie Blevins, Lisa N. Kinch, Kelly A. Servage, Nathan M. Stewart, Hillery Fields Gray, Amanda K. Casey, Kim Orth
This study investigates the role of FicD in regulating BiP AMPylation and UPR signaling in mouse embryonic fibroblasts under different stress conditions, revealing its impact on stress recovery and protein secretion.
Proceedings of the National Academy of Sciences · Sep 11, 2024Peer-reviewedMolecular Biology
Amanda K. Casey, Nathan M. Stewart, Naqi Zaidi, Hillery Fields Gray, Amelia Cox, Hazel A. Fields, Kim Orth
This study shows FicD regulates UPR responses in the murine liver during mild stress but not chronic or acute UPR induction.
Biochimie · May 11, 2024Peer-reviewedPhysiology
Varsha Bhargava, Courtney D. Goldstein, Logan Russell, Lin Xu, Murtaza Ahmed, Wei Li, Amanda K. Casey, Kelly A. Servage, Rahul Krishna Kollipara, Zachary Picciarelli, Ralf Kittler, Alexander N. Yatsenko, Michelle A. Carmell, Kim Orth, James F. Amatruda, , Michael Buszczak
The paper identifies GCNA as a conserved regulator of genome stability in germ cells across species, showing its role in preventing DNA damage and maintaining fertility.
Developmental Cell · Dec 12, 2019Peer-reviewedDevelopmental Biology
Karoliina Stefanius, Kelly A. Servage, Marcela de Souza Santos, Jason Toombs, Hillery Fields Gray, Suneeta Chimalapati, Min S. Kim, Rolf A. Brekken, Kim Orth
Cancer cell exosomes initiate malignant cell transformation by causing random genetic changes in recipient cells, leading to aggressive tumor growth in mice.
bioRxiv · Jul 3, 2018 · PreprintCancer Biology
Andrew T. Moehlman, Amanda K. Casey, Kelly Servage, Kim Orth, Helmut Krämer
This study shows that Fic-mediated AMPylation of BiP is essential for photoreceptors to adapt to light stress in Drosophila.
bioRxiv · Jun 15, 2018 · PreprintCell Biology