Chie Motono

Screening and machine-learning assisted prediction of translation-enhancing peptides reducing ribosomal stalling in Escherichia coli

The paper screens translation-enhancing peptides (TEPs) in E. coli and develops a machine learning model to predict their activity, showing strong correlation with experimental results.

CrypToth: Cryptic pocket detection through mixed-solvent molecular dynamics simulations based topological data analysis

CrypToth identifies cryptic sites on proteins using mixed-solvent molecular dynamics and topological data analysis, achieving high accuracy in hotspot prediction.

Atg15 is a vacuolar phospholipase that disintegrates organelle membranes

This study shows that Atg15 is a vacuolar phospholipase that disintegrates organelle membranes by degrading phospholipids in acidic environments.

Imputation-free reconstructions of three-dimensional chromosome architectures in human diploid single-cells using allele-specified contacts

This paper introduces an algorithm to reconstruct 3D chromosome structures in single human diploid cells using allele-specific SNVs without imputation, achieving resolutions of 40-kb to 1-Mb.