Author

Takatsugu Hirokawa

University of TsukubaORCID 0000-0002-3180-5050Unclaimed ORCID profile · follow to get notified of new preprints

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Takatsugu Hirokawa1 paper

Biology Disciplines

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Biochemistry· 1 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Chie MotonoiD· 1 shared Genki KudoiD· 1 shared Hina Sakai· 1 shared Hiroshi TsugawaiD· 1 shared Jun KosekiiD· 1 shared Katsuya OhbuchiiD· 1 shared Kazuya TsumagariiD· 1 shared Keisuke YanagisawaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperBioinformatics

Chie MotonoORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintMay 8, 2026

Elucidation of the anti-inflammatory mechanism of isoliquiritigenin from Glycyrrhiza uralensis using activity-based protein profiling

Hina Sakai, Mi Hwa Chung, Taiki Nakaya…·Hiroshi Tsugawa

This study identifies L-PGDS as a covalent target of isoliquiritigenin, revealing its anti-inflammatory mechanism through suppression of PGD2 production.

DOI 10.64898/2026.05.05.722967

proteomicsexperimental assay

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BioinformaticsJournal of Chemical Information and ModelingPeer-reviewedMay 22, 2025

CrypToth: Cryptic pocket detection through mixed-solvent molecular dynamics simulations based topological data analysis

Jun Koseki, Chie Motono, Keisuke Yanagisawa…·Kenichiro Imai

CrypToth identifies cryptic sites on proteins using mixed-solvent molecular dynamics and topological data analysis, achieving high accuracy in hotspot prediction.

13 citationstop 3%

protein structurestatistical model

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