Author

Chih‐Jen Cheng

University of IowaORCID 0000-0002-6908-3428Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:imaging· 1

Frequent Co-Authors

Bi‐Chang CheniD· 1 shared Biswajit PadhyiD· 1 shared Chia-Ming LeeiD· 1 shared Chou‐Long HuangiD· 1 shared Danish IdreesiD· 1 shared Jian XieiD· 1 shared Po-Yen Lin· 1 shared XUEJIAO TIAN· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 16 mutual co-author links

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1 shared paperBioengineering

Bi‐Chang ChenORCID

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2 papers

Recent·Most cited

Dodecagon light-sheet fluorescence microscopy for large-volume imaging without striping artifacts

Chia-Ming Lee, Po-Yen Lin, XUEJIAO TIAN, Yijuang Chern, Chih‐Jen Cheng, Bi‐Chang Chen

This paper introduces dodecagon light-sheet fluorescence microscopy (dodecaLSFM) to eliminate striping artifacts in large-volume imaging, demonstrating its effectiveness in imaging whole mouse brain vasculature and combining with expansion microscopy for 3D cellular resolution.

Optics Express · Aug 25, 2026Peer-reviewedBioengineering

Endoplasmic reticulum-mitochondrion disconnection promotesmetabolic reprogramming and cystogenesis in polycystic kidneydisease

Biswajit Padhy, Jian Xie, Danish Idrees, Chih‐Jen Cheng, Chou‐Long Huang

This study shows that ER-mitochondria disconnection in ADPKD causes metabolic reprogramming and cyst formation, and restoring this connection reduces disease symptoms.

bioRxiv · Oct 31, 2025 · PreprintMolecular Biology