A phage-encoded small RNA that mimics chimeric guide to inhibit CRISPR-Cas9
Yuehua Chen, Peng Zhao, Chenmin Guo, Dandan Chen, Caihong Yun, Jun Chen, Liang Liu
The paper identifies a phage-encoded small RNA that mimics the CRISPR-Cas9 guide RNA to inhibit the system and demonstrates its reprogrammability for DNA cleavage and trans-cleavage.
bioRxiv · Jun 3, 2026 · PreprintBiochemistry