Peng Zhao

WheatPanRef: a unified linear pan-reference genome for wheat genomics

WheatPanRef provides a unified linear pan-reference genome for wheat, improving read alignment and enabling integration of genomic resources across diverse accessions.

Spatial synaptic regularization stabilizes learning across biological and artificial neural networks

This study identifies spatial synaptic organization as a mechanism for stabilizing learning and introduces Spatial Synaptic Regularization (SSR) to improve AI learning stability.

A phage-encoded small RNA that mimics chimeric guide to inhibit CRISPR-Cas9

The paper identifies a phage-encoded small RNA that mimics the CRISPR-Cas9 guide RNA to inhibit the system and demonstrates its reprogrammability for DNA cleavage and trans-cleavage.

A Continuum of Atrial Peristalsis Initiates the Bicuspid to Quadricuspid Valve Transition

The paper shows that atrial peristalsis drives the transition from a bicuspid to quadricuspid valve in zebrafish through Klf2a-Snai1b signaling and shear stress alignment.

Photoaged microplastics disrupt endothelial stretch-sensitive ion channels to impair calcium signaling and vascular integrity

This study shows photoaged microplastics impair endothelial calcium signaling and vascular integrity by disrupting Piezo1-Notch mechanotransduction.

Mucin-type O-glycans regulate proteoglycan stability and chondrocyte maturation

This study shows that mucin-type O-glycans regulate proteoglycan stability and chondrocyte maturation through interactions with heparan sulfate proteoglycans.