Liang Liu

The paper identifies a phage-encoded small RNA that mimics the CRISPR-Cas9 guide RNA to inhibit the system and demonstrates its reprogrammability for DNA cleavage and trans-cleavage.

The paper identifies two novel proteins, EGC-2 and EGC-3, that are essential for E granule assembly and small RNA homeostasis in C. elegans using TurboID-based proximity labeling and RNAi screening.

This study identifies OPTN's role in axonal mitochondria transport and shows its loss contributes to neurodegeneration in models of ALS and NTG.