Aurora Gómez-Durán

This study shows genetic and chemical partial reprogramming targets senescent cells to reduce aging-related inflammation and improve mitochondrial function in aged mice without restoring proliferation.

This study shows rapamycin reverses gene expression in Ccm3-deficient endothelial cells and, when combined with lapatinib, reduces lesion volume in a chronic CCM model.

The paper identifies cryptic mitochondrial DNA mutations in single cells across species and tissues, showing their association with ageing and pathophysiological processes.

The paper develops a protocol using Oxford Nanopore Sequencing to accurately detect CpG methylation in human mtDNA, overcoming limitations of WGBS.

The paper identifies a metabolic shift involving amino acid availability and mitochondrial biogenesis as the mechanism underlying recovery in reversible infantile respiratory chain deficiency.