Manuel Collado

Extracellular Vesicles from Senescent Tumor Cells Are Necessary and Sufficient to Drive Paracrine Senescence

This study shows that extracellular vesicles from senescent tumor cells are both necessary and sufficient to induce paracrine senescence in neighboring cells.

SENOMORPHIC EFFECT OF GENETIC AND CHEMICAL PARTIAL REPROGRAMMING

This study shows genetic and chemical partial reprogramming targets senescent cells to reduce aging-related inflammation and improve mitochondrial function in aged mice without restoring proliferation.

Transcriptional repression of SOX2 by p53 in cancer cells regulates cell identity and migration

This paper shows that TP53 represses SOX2 in cancer cells, affecting cell identity and migration, with implications for metastasis in breast cancer.

Epigenetic reprogramming of a distal developmental enhancer cluster drives SOX2 overexpression in breast and lung cancer

The paper identifies an enhancer cluster that drives SOX2 overexpression in breast and lung cancer by altering chromatin accessibility and regulatory mechanisms.