The paper identifies insulin receptor ubiquitination as a regulator of collagen secretion in human skin through comparative ubiquitinomics of healthy and CYLD syndrome skin.

Communications Biology · Sep 17, 2026Peer-reviewedCell Biology

TUG protein acts through a disordered region to organize the early secretory pathway

Anup Parchure, Helen Tejada, Zhiqun Xi, Yeongho Kim, Maohan Su, You Yan, Omar Julca-Zevallos, Abel R. Alcázar-Román, Marie Villemeur, Xinran Liu, Derek K. Toomre, Ishier Raote, Jonathan S. Bogan

This study identifies TUG's role in maintaining the ERGIC as a distinct organelle by organizing anterograde trafficking and preventing membrane homeostasis disruption.

Nature Communications · Jul 1, 2025Peer-reviewedCell Biology

p125A (Sec23ip) couples COPII coat assembly with donor-acceptor membrane organization to facilitate tunnel-based traffic.

Kimberly R. Long, Gazal Singh, Marie Villemeur, Nathalie Brouwers, Vivek Malhotra, Ishier Raote, Meir Aridor

This study shows p125A stabilizes donor-acceptor membrane contact and promotes COPII outer layer assembly, facilitating tunnel-based collagen traffic.

bioRxiv · May 7, 2025 · PreprintCell Biology

Biallelic TANGO1 mutations cause a novel syndromal disease due to hampered cellular collagen secretion

Caroline Lekszas, Ombretta Foresti, Ishier Raote, Daniel Liedtke, Eva‐Maria König, Indrajit Nanda, Barbara Vona, Peter De Coster, Rita G. E. C. Cauwels, Vivek Malhotra, Thomas Haaf

This paper identifies biallelic TANGO1 mutations causing a novel syndromal collagenopathy in humans, leading to multiple systemic abnormalities.

eLife · Feb 26, 2020Peer-reviewedGenetics