Joseph Inns

This study uses single-cell proteomics to identify protein-defined chondrocyte states and other cell populations in human osteoarthritic joints, complementing single-cell transcriptomics.

The paper identifies insulin receptor ubiquitination as a regulator of collagen secretion in human skin through comparative ubiquitinomics of healthy and CYLD syndrome skin.

The paper introduces a pipeline for single-cell proteomics analysis that addresses challenges in data processing and annotation using context-aware methods and large language models.

The paper introduces a cost-effective single-cell proteomics method to analyze skin tumors in CYLD cutaneous syndrome, identifying a novel tumor-associated macrophage signature.

This study identifies non-canonical NF-κB signalling as a therapeutic target in CYLD cutaneous syndrome and shows that IKK inhibition reduces tumor viability in patient-derived models.