The paper identifies insulin receptor ubiquitination as a regulator of collagen secretion in human skin through comparative ubiquitinomics of healthy and CYLD syndrome skin.

Communications Biology · Sep 17, 2026Peer-reviewedCell Biology

Development and Characterisation of a Versatile Single-Domain Antibody Specific for M1-linked Ubiquitin Chains

Julian Koch, Shun‐Je Bhark, Verian Bader, Berthe Katrine Fiil, Blanca Lopez- Mendez, Josefine Bebe Rasthoej, Dominik Priesmann, Oscar Mejias-Gomez, Marta Braghetto, Guillermo Montoya, Mads Gyrd‐Hansen, Konstanze F. Winklhofer, Steffen Goletz, Jonathan N. Pruneda, Rune Busk Damgaard

This paper develops a single-domain antibody specific for M1-linked ubiquitin chains, enabling their detection and analysis across multiple applications.

bioRxiv · Jul 6, 2026 · PreprintBiochemistry

The binding of OTULIN restrains LUBAC activity to prevent TNF-driven immunopathology

Wenxin Lyu, Berthe Katrine Fiil, John Rizk, Majken Kjær, Max Benjamin Sauerland, Biao Ma, Malin Jessen, Rune Busk Damgaard, Mads Gyrd‐Hansen

This study shows that OTULIN's interaction with LUBAC limits its activity, preventing TNF-driven inflammation and immunopathology.

bioRxiv · Feb 28, 2026 · PreprintMolecular Biology

M1-linked Ubiquitination by LUBAC Regulates AMPK Activity and the Response to Energetic Stress

Camilla Reiter Elbæk, Sophie Gradinaru, Anna M. Dahlström, Alexander Frueh, Akhee Sabiha Jahan, Joyceline Cuenco, Anna L. Aalto, John Rizk, Simon A. Hawley, Sarah N. J. Franks, Michael Stumpe, Srinivasa Prasad Kolapalli, Chris Kedong Wang, Cara J. Ellison, Ximena Hildebrandt, , Rune Busk Damgaard

This study shows LUBAC activates AMPK and OTULIN restricts it, affecting metabolic responses to energy stress in cells, mice, and flies.

Cell Death and Differentiation · Feb 13, 2026Peer-reviewedCell Biology