IKAROS facilitates antigen escape in the face of CD19- and CD22-targeted therapies for B-cell acute lymphoblastic leukemia
Pablo Domizi, Jolanda Sarno, Astraea Jager, Milton J. Merchant, Kaithlen Zen Pacheco, Sean A. Yamada‐Hunter, Maria Caterina Rotiroti, Yuxuan Liu, Reema Baskar, Warren D. Reynolds, Brian J. Sworder, Bita Sahaf, Sean C. Bendall, Charles Grenfell Mullighan, Ash A. Alizadeh, , Kara Lynn Davis
This study identifies IKAROS as a factor associated with antigen escape in B-ALL, showing that low IKAROS levels lead to reduced B-cell antigen expression and resistance to CD19- and CD22-targeted therapies.
Nature Communications · Apr 23, 2025Peer-reviewedCancer Biology