Author

Sean A. Yamada‐Hunter

Stanford Cancer InstituteORCID 0000-0002-4372-6587Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Synthetic Biology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:mouse· 1 Assay:protein sequence· 1

Frequent Co-Authors

Crystal Lee MackalliD· 3 shared Elena SotilloiD· 3 shared Carolyn Ruth BertozziiD· 2 shared Jonathan Lee YangiD· 2 shared Louai LabaniehiD· 2 shared Alice Y. TingiD· 1 shared Allison Barz LeahyiD· 1 shared Ash A. AlizadehiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersSynthetic Biology

Crystal Lee MackallORCID

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3 papers

Recent·Most cited

AAV delivered lysosome-targeting chimeras mediate sustained antibody depletion in vivo

Jonathan Lee Yang, Kang Yong Loh, Cindy R. Sandoval Espinoza, Dina Schuster, Sean A. Yamada‐Hunter, Louai Labanieh, Elena Sotillo, Crystal Lee Mackall, Karl A. Deisseroth, Carolyn Ruth Bertozzi

This paper develops GELYTACs, lysosome-targeting chimeras that deplete IgG in vivo via AAV delivery, showing sustained antibody depletion in mice.

bioRxiv · Sep 10, 2026 · PreprintSynthetic Biology

IKAROS facilitates antigen escape in the face of CD19- and CD22-targeted therapies for B-cell acute lymphoblastic leukemia

Pablo Domizi, Jolanda Sarno, Astraea Jager, Milton J. Merchant, Kaithlen Zen Pacheco, Sean A. Yamada‐Hunter, Maria Caterina Rotiroti, Yuxuan Liu, Reema Baskar, Warren D. Reynolds, Brian J. Sworder, Bita Sahaf, Sean C. Bendall, Charles Grenfell Mullighan, Ash A. Alizadeh, , Kara Lynn Davis

This study identifies IKAROS as a factor associated with antigen escape in B-ALL, showing that low IKAROS levels lead to reduced B-cell antigen expression and resistance to CD19- and CD22-targeted therapies.

Nature Communications · Apr 23, 2025Peer-reviewedCancer Biology

Directed Evolution of Genetically Encoded LYTACs for Cell-Mediated Delivery

Jonathan Lee Yang, Sean A. Yamada‐Hunter, Louai Labanieh, Elena Sotillo, Joleen S. Cheah, David S. Roberts, Crystal Lee Mackall, Carolyn Ruth Bertozzi, Alice Y. Ting

The paper describes the development of genetically encodable LYTACs (GELYTACs) for targeted protein degradation using engineered T-cells, showing efficacy in secreting and delivering the therapeutics.

Proceedings of the National Academy of Sciences · Mar 21, 2024Peer-reviewedSynthetic Biology