Ian Martin

This study identifies genetic modifiers of maneb-induced dopaminergic neurodegeneration in Drosophila using genome-wide association analysis and validates candidate genes involved in Wnt signaling.

The paper identifies two genes, luna and CG32264, that mediate resistance to paraquat-induced dopaminergic neurodegeneration in Drosophila, with CG32264's mammalian ortholog linked to human Parkinson's disease risk.

This study identifies glutathione deficiency as a key factor in age-related dopamine neuron loss and links it to lifespan in Drosophila, with implications for human Parkinson's disease.

This paper introduces a method to specifically label nascent proteins in Drosophila brain cells using PhAc-OPP and PGA, revealing age-related declines in neuronal protein synthesis.

This study shows that dietary amino acid levels modulate LRRK2-induced neurodegeneration in Drosophila and rat neurons by affecting protein synthesis and autophagy.

The paper identifies genetic modifiers of LRRK2 G2019S-induced neurodegeneration in Drosophila using the DGRP, revealing 177 candidate genes and four significant modifiers affecting locomotor dysfunction.