BiochemistryJournal of Biological ChemistryPeer-reviewed
U1 snRNP-Specific U1C Acts as the Gatekeeper of the Survival of Motor Neurons (SMN) Complex in snRNP Biogenesis
Duc Minh Ngu, Sanat Myti, Ayesha Ali Khan…·Jeongsik Yong
This study identifies U1C as a key regulator of the SMN complex in snRNP biogenesis, showing that U1C mutations disrupt Sm core assembly and inhibit snRNP formation in cancer.