Byung Ran So

This study identifies U1C as a key regulator of the SMN complex in snRNP biogenesis, showing that U1C mutations disrupt Sm core assembly and inhibit snRNP formation in cancer.

The paper identifies a TOMM40-APOE chimera (T9A2) that links APOE4 to mitochondrial dysfunction and oxidative stress, suggesting a new pathway in Alzheimer's disease pathogenesis.

Moderate U1 snRNP inhibition raises cancer cell migration and invasion by up to 500% and shortens 3'UTRs in many genes, while U1 overexpression has the opposite effects.