U1 snRNP-Specific U1C Acts as the Gatekeeper of the Survival of Motor Neurons (SMN) Complex in snRNP Biogenesis
Duc Minh Ngu, Sanat Myti, Ayesha Ali Khan, Jeanne Keita, Tessa Moore, Paul Andega, Alaa Aziz, Ritu Raj, Kayunta L. Johnson-Winters, Eul Hyun Suh, Byung Ran So, Jeongsik Yong
This study identifies U1C as a key regulator of the SMN complex in snRNP biogenesis, showing that U1C mutations disrupt Sm core assembly and inhibit snRNP formation in cancer.
Journal of Biological Chemistry · Jul 22, 2025Peer-reviewedBiochemistry