Activity-based CRISPR Scanning Uncovers Allostery in DNA Methylation Maintenance Machinery
Kevin Chun-Ho Ngan, Samuel M. Hoenig, Hui Si Kwok, Nicholas Z. Lue, Pallavi M. Gosavi, David A. Tanner, Emma M Garcia, Ceejay Lee, Brian B. Liau
This study uses activity-based CRISPR scanning to identify allosteric sites in DNMT1 and UHRF1, revealing gain-of-function mutations that enhance DNA methylation activity.
eLife · Feb 10, 2023Peer-reviewedGenomics